Mechanical Mitral Valve Prosthesis Thrombosis: A Case Report
Case studies
Viktorija Pareikaitė
Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences image/svg+xml
https://orcid.org/0009-0003-9703-5751
Silvija Makrickaitė
Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences image/svg+xml
https://orcid.org/0009-0005-8669-5441
Giedrė Bakšytė
Department of Cardiology, Lithuanian University of Health Sciences, Kaunas Clinics
https://orcid.org/0000-0003-4113-004X
Published 2025-03-24
https://doi.org/10.15388/Amed.2025.32.1.13
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Keywords

prosthetic valve thrombosis
thrombolysis

How to Cite

1.
Pareikaitė V, Makrickaitė S, Bakšytė G. Mechanical Mitral Valve Prosthesis Thrombosis: A Case Report. AML [Internet]. 2025 Mar. 24 [cited 2025 Mar. 29];32(1):131-6. Available from: https://www.zurnalai.vu.lt/AML/article/view/38588

Abstract

Background: A rare but serious complication of heart valve replacement, prosthetic valve thrombosis carries significant risks of morbidity and mortality. Effective management depends on prompt diagnosis and the appropriate treatment, often involving fibrinolytic agents. Protocols using slower infusion rates and lower doses of these agents have led to improved therapy outcomes.
Clinical case: We report a case of a 56-year-old man admitted to the Lithuanian University of Health Sciences Kaunas Clinics due to mechanical mitral valve prosthesis thrombosis complicated by a respiratory failure and atrial fibrillation. The patient was treated with ultraslow thrombolysis with alteplase. The function of the mechanical valve prosthesis became normal, and the patient was discharged from the hospital.
Discussion and Conclusions: Managing prosthetic valve thrombosis is challenging due to overlapping clinical features with other diagnoses and the lack of consensus on the treatment methods. Slow-infusion, low-dose thrombolytic therapy with alteplase can be a life-saving intervention with a high success rate.

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